Die Atmung hat sich durch die regelmäßige Anwendung deutlich verbessert und er ist wieder viel leistungsfähiger. Symptom scores (mean ± SD; ∗ P < 0.05). The expiry date is given on the product itself and on the outer packaging. Respiratory infections cause 30% to 40% of all doctor visits in the UK and 75–100 million doctor visits per year in the US [1]. Nevertheless, because of varying baseline parameters, direct comparisons of the BSS between studies are informative only to a limited extent. Change of fractional exhaled nitric oxide for a sub-group of patients performed on-site over study visit at selected study sites follow-up. The physicians’ assessments showed that the patients’ general health improved in both groups from V1 to V2. The physicians’ assessments showed that the BSS and the individual scores for the symptoms of cough, chest pain when coughing, auscultation findings, dyspnea, and expectoration decreased significantly in both groups from V1 to V2 (P < 0.05) (Figure 1, Table S1). Is it possible to use Ectoin®-containing products with other OTC medications, e.g. The ectoine inhalation solution (Ectoin® inhalation solution, bitop AG, Dortmund, Germany) used in this study contained ectoine (1.3%) and sea salt in water. Thus, the reduction in the mean BSS of 5.13 ± 3.11 in the ectoine group in our study is greater than the reductions reported for the abovementioned placebo groups. The clinical study is a single-center efficacy and feasibility study involving patients with inflammation and airway obstruction in Germany. Reduction of neutrophilic lung inflammation by inhalation of the ... 6, pp. Pharmacol Res. bei der Anwendung im Air One Inhalator). The Bronchitis Severity Score (BSS) was used to assess the severity of five major bronchitis symptoms: cough, chest pain when coughing, dyspnea, expectoration, and auscultation findings on a 5-point scale (0 = no symptoms, 1 = mild, 2 = moderate, 3 = severe, and 4 = very severe). Vernebelungstechnik: Stationäres Ultraschall-Inhaliergerät mit 1,7 Megahertz. . Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study. Information provided by (Responsible Party): The goal of this multi-centre, prospective, open-label, single-arm, post-market clinical follow-up study is to further strengthen the already existing clinical evidence for supportive treatment and symptoms alleviation in asthma by evaluating the clinical efficacy of Ectoin® Inhalation Solution in paediatric and adults patients with mild to moderate asthma. National Library of Medicine Clin Chest Med. U. Sydlik, I. Gallitz, C. Albrecht, J. Abel, J. Krutmann, and K. Unfried, “The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation,” American Journal of Respiratory and Critical Care Medicine, vol. Enter multiple addresses on separate lines or separate them with commas. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Ectoin® Containing Inhalation Solution (EIL07) (Class-IIa MDD legacy medical device). Two treatment-related adverse events occurred in the ectoine group and one in the saline group. "PARI ProtECT inhalation solution" (Pari, Germany) and "Ectodose inhalation ampoules" (Solinea, Poland). -, MacNee W. Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD) Biochem Soc Trans. 2 How does Ectoin® work? The Effectiveness of the Bacteria Derived Extremolyte Ectoine for the Treatment of Allergic Rhinitis. U of M researchers’ device is more energy efficient and versatile than past models. This study investigated ectoine inhalation solution for the treatment of acute bronchitis and/or acute respiratory infections. Reduction of inflammatory markers IL8 and granulocytes was greater after treatment with Ectoin compared to placebo (12% for IL8, 29% for neutrophils). 2, pp. 437–445, 2005. 4, pp. 08, pp. The Peak Expiratory Flow (applicable for both mPEF and ePEF) is defined as the maximum speed of expiration as measured with the Smart Peakflow (best of 3 measurements). Mehr Medikamente anwendbar. In patients with neutrophilic lung inflammations, the application of ectoine inhalation solution significantly reduced the levels of two inflammatory factors—sputum neutrophils and nitrogen oxides . Wellmerling J, Rayner RE, Chang SW, Kairis EL, Kim SH, Sharma A, Boyaka PN, Cormet-Boyaka E. FASEB J. The results of the EFECT study support the outcome of other studies that the membrane stabilizing Ectoin reduces epithelia derived inflammatory processes. Wellmerling J, Rayner RE, Chang SW, Kairis EL, Kim SH, Sharma A, Boyaka PN, Cormet-Boyaka E. FASEB J. Ectoin® is the only cosmetic anti-pollution active ingredient, which is also approved for anti-pollution medical applications. Ectoin® T. Bernard, M. Jebbar, Y. Rassouli, S. Himdi-Kabbab, J. Hamelin, and C. Blanco, “Ectoine accumulation and osmotic regulation in Brevibacterium linens,” Journal of General Microbiology, vol. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. App für Praxisbedarf. Epub 2021 May 6. Besides demonstrating beneficial effects on inflammatory sputum parameters, the study proves the feasibility of the therapeutic approach in an aged study group. A multi-talent for skin and mucous membranes. 2019 Mar;276(3):775-783. doi: 10.1007/s00405-019-05324-9. Dieses ist aber. Did you know that Ectoin® has a long-lasting effect? Please enable it to take advantage of the complete set of features! 1, pp. Consult your healthcare provider or pharmacist for advice, before using this Medical Device, if you are: • not sure whether you are pregnant or not. Aging and induced senescence as factors in the pathogenesis of lung emphysema. (. Ectoin ® has a physical mode of action: it surrounds the mucous membranes or the skin with a protective coating . 2009 Jul 1;180(1):29-35. doi: 10.1164/rccm.200812-1911OC. bi-medEctoin® easy breathe ist eine sterile Lösung einzig bestehend aus 13% bi-medEctoin® und Wasser. Experienced an acute asthma exacerbation requiring emergency room treatment within 4 weeks or hospitalisation within 8 weeks of Visit 1. Preis ca. 1, pp. The duration of participation in the clinical study will be 42±2 days (6 weeks) from enrollment). The biophysical stabilization of the cells reverts natural cell death to a level as it would occur without the effect of pollutants and, therefore, leads to a reduction of the inflammation. The baseline measurement is represented by the mean of the 7 daily values recorded during the run-in period (week 1) and the end-of-treatment measurement is the mean of morning PEF during week 4 (at least 7 days, V3). doi: 10.1099/00221287-139-1-129. B. Kemmerich, R. Eberhardt, and H. Stammer, “Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough,” Arzneimittel-Forschung/Drug Research, vol. The other authors report no conflicts of interest in this work. eCollection 2022. In some medical devices ingredients are used, that are not suited for the use in very young children (e.g. It was first found in microorganisms from extreme osmotic habitats. The differences in the area under the curve for the symptoms of dyspnea and auscultation findings were significant in favor of ectoine (P < 0.05). The study lasted 17 days, comprising an inclusion visit (V1, day 1), a final visit (V2, day 7), and a follow-up questionnaire (FU, day 17). Will the Ectoin®-containing products interact with my prescription medication? PMC Insbesondere bei Pferden, die unter chronischen Atemwegserkrankungen wie Equinem Asthma leiden, kann die präventive Inhalation symptomfreie Phasen verlängern und neue Akutzustände verhindern. It's an amino acid found within and derived from several types of bacteria, but don't be put off by the word "bacteria.". The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Today, the outstanding cell-protecting properties of Ectoin®find application in medical devices and in products for the life science industry. HHS Vulnerability Disclosure, Help analgesics, antibiotics, cold remedies, herbals etc.? Journal of General Microbiology. 8600 Rockville Pike Inhalierzeit: 7,5 ml dauerten im Test etwa 5 bis 10 Minuten . 2021 Feb 9;2021:8885032. doi: 10.1155/2021/8885032. We thank Yann Reydelet for his contribution to the project management and Gena Kittel for editing the manuscript. All adverse events were documented, and their relations to the treatment were evaluated by the investigators. This lies protective and stabilizing on the mucous membrane and thus prevents drying out. Treatment lasted 7 days, being administered from V1 to V2. This prospective, controlled, observational study comprised an inclusion visit (day 1), a final visit (day 7), and a follow-up questionnaire (day 17). Conclusion: The general effectiveness of the treatment was evaluated by investigators and patients independently at V2 using the Integrative Medicine Outcome Scale as “complete recovery”, “major improvement”, “slight/moderate improvement”, “no change”, or “deterioration”. “Exposure of the lungs to air pollution still poses a problem for the inhabitants of industrialised countries, leading to diseases like COPD with a high economic burden, and it is expected that this disease will be ranked as number three of death causing diseases within the next years. Respir Res. Unauthorized use of these marks is strictly prohibited. Baseline mild to moderate uncontrolled asthma, defined as meeting at least one of the following: Willingness of the participants to actively participate in the study and to come to the scheduled visits. Scientific Reports. OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the . Bitop AG Announces Start of Clinical Trial with Ectoin Inhalation ... B. Kemmerich, “Evaluation of efficacy and tolerability of a fixed combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough,” Arzneimittel-Forschung/Drug Research, vol. Together with members of the department of Traumatology and Hand Surgery and the department of Angiology, Pneumology and Cardiology of the University Clinics Düsseldorf, they were able to show that after exposure to pollutants the life span of the inflammatory cells is prolonged and thereby the inflammation is likely to be increased. No, Ectoin® is neither addictive nor does it cause withdrawal symptoms. Completion of ACQ-7 questionnaire and FeNO assessment. This fact is proven by results of various experiments. Multicentre Post-market Study of Ectoin® Inhalation Solution in ... Federal government websites often end in .gov or .mil. Wir verwenden Cookies. Record Verification: October 2010 M. Kroker, U. Sydlik, A. Autengruber et al., “Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model,” Particle and Fibre Toxicology, vol. Then please get in contact with our medical service. Applied Microbiology and Biotechnology. In another study, the combination of thyme herb with primrose root reduced the mean BSS by 6.2, and the placebo reduced the same mean by 4.1 [19]. Zhang T, Cui T, Cao Y, Li Y, Li F, Zhu D, Xing J. Antonie Van Leeuwenhoek. A multi-talent for skin and mucous membranes. Kroker M, Sydlik U, Autengruber A, Cavelius C, Weighardt H, Kraegeloh A, Unfried K. Part Fibre Toxicol. No, Ectoin®-containing products do not make you tired. The evening PEF is to be measured in the evening at bedtime. Accessibility This study was funded by bitop AG (Dortmund, Germany). Ectoine inhalation solution seems to be slightly more effective than saline inhalation solution for the treatment of acute bronchitis and acute respiratory infections. Response to treatment is recorded at day 7 and day 14 by the physician and in daily by the patient in a dairy. A. Douros, E. Bronder, F. Andersohn et al., “Herb-induced liver injury in the berlin case-control surveillance study,” International Journal of Molecular Sciences, vol. While the untreated, UV-stressed area showed a 40% decrease in viable Langerhans cells, 0.5% Ectoin . NCI CPTC Antibody Characterization Program, Karrasch S, Holz O, Jorres RA. Ectoine - OEL Fastrac with ADE - Affygility Solutions has many positive characteristics: Applied in humans, it protects the mucous membranes in the eyes, nose, lungs , mouth and throat. 1993;139(1):129–136. PARI Protect inhalation solution with ecoToin ampoules, 10x2.5 ml On the skin it was proven, that the moisturizing effect after 12 days of treatment persists for 7 more days if the treatment is stopped. Change of quality of life questionnaires, Paediatric Asthma Quality of Life Questionnaire (PAQLQ) score is applicable for children up to 12 years and Asthma Quality of Life Questionnaire (AQLQ+12) is applicable for patients aged 12-years and older, Change of asthma control questionnaire (ACQ-7), Change in Morning Peak Expiratory Flow [ Time Frame: Baseline (week 1) upto week 4 ], Change in Evening Peak Expiratory Flow [ Time Frame: Baseline (week 1) to week 2, week 3 and week 4 ], Change in Morning/Evening Peak Expiratory Flow [ Time Frame: Week 4 to week 5 ], Change Morning PEF [ Time Frame: Baseline (week 1) to each treatment week (week 2 and week3) ], Rescue medication [ Time Frame: Baseline (week 1) upto week 4 ], FeNO (fractional exhaled nitric oxide) assessment [ Time Frame: Baseline (week 1) upto week 4 ], FeNO (fractional exhaled nitric oxide) assessment [ Time Frame: Week 4 to week 5 ], Quality of life questionnaire PAQLQ or AQLQ+12 [ Time Frame: Week 2 upto week 5 ], Change in Asthma control questionnaire (ACQ-7) [ Time Frame: Baseline (week 1) upto week 4 ], Change in Asthma control questionnaire (ACQ-7) [ Time Frame: Week 4 to week 5 ], Male and female subjects aged≥ 6 years to 60 (included), A documented clinical history of asthma for a period of at least 6 months, Forced Expiratory Volume in 1 Second (FEV1): 60%
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